Central Dogma of Molecular Biology Free Essay, Term Paper and Book Report
Describe the Central Dogma of Molecular Biology
The Central Dogma refers to the flow of genetic information in biological systems. According to Watson-Crick,
Deoxyrobonucleic Acid (DNA) consists of two polynucleotides chains which are held together by hydrogen bonds
complementary bases: Adenine (A): Thymine (T), T is however replaced with Uracil (U) in Ribonucleic Acid (RNA)
and Guanine (G): Cytosine (C). The strands of polynucleotides run antiparallel, 5 to 3 end.
DNA replication is the process that occurs in all the cells, whereby an entire double-stranded DNA is copied
to produce a second, identical DNA double helix. It begins at specific locations in the genome, called
origins. DNA replication is semi-conservative whereby each polynucleotide of the parental DNA acts as a
template for base-pairing to form complementary strand. This is proven by Meselson and Stahl experiment where
they grew E.coli on a heavy nitrogen isotope, 15NH4Cl for 14 generations and then transferred to a normal
heavy nitrogen isotope, 14NH4Cl. The DNA in the bacteria consists of half 15N an......
Word Count: 1165
Page Count: 4.6 (250 words a page / double spaced)
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